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The study was approved by the ethics committee of the Institut fur Hypertoniker in Vienna and was conducted in accordance with the International Conference on Reese group reading pa ICH guidelines for Good Clinical Practice GCP and all applicable regulatory requirements, including, where applicable, the version of the Declaration of Helsinki. Subjects were allocated to the two treatment sequences fluticasone furoate placebo or placebo fluticasone furoate. Nasal symptoms sneeze, itch, rhinorrhoea and obstruction, eye symptoms watery eyes, itchy eyes, red eyes and other symptoms cough, itchy throat, itchy ears were scored on a categorical scale at screening, pre dose on day and every minutes during the challenges on days and. An day course of mcg of fluticasone furoate statistically significantly reduced symptoms of allergic rhinitis including associated eye symptoms elicited by an allergen challenge commencing one hour after dosing, compared with placebo. Efficacy and safety of an oral formulation of cetirizine and prolonged release pseudoephedrine versus budesonide nasal spray in the management of nasal congestion in allergic rhinitis. The human pharmacology of fluticasone propionate.
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